Certain compounds that uncouple (or delink) the electron transport from oxidative phosphorylation are known as uncouplers. They increase the inner mitochondrial membrane's protons (H*) permeability. Consequently, there is no ATP synthesis. The energy associated with the movement of electrons is lost as heat. The uncouplers allow (often at accelerated rate) oxidation of substrates (via NADH or FADH,) without ATP formation e.g., 2, 4-dinitrophenol (DNP); dinitrocresol, penta-chlorophenol, etc.